Outline introduction terms, basis, classification, stats primitive germ cell tumors teratomas mature immature mixed gonadoblastoma 3. Experience with adjuvant chemotherapy is limited, but considering the effectiveness of chemotherapy in tumors other than dysgerminoma and its effectiveness in advancedstage dysgerminoma, adjuvant chemotherapy is likely to be effective and to allow recovery of reproductive potential in patients with an intact ovary, fallopian tube, and uterus. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. An impression of germ cell tumor of ovary, dysgerminoma was made.
Signs of ovarian germ cell tumor are swelling of the abdomen or vaginal bleeding after menopause tests that examine the ovaries, pelvic area, blood, and ovarian tissue are used to detect find and diagnose ovarian germ cell tumor. Jun 23, 2007 dysgerminoma is the most common malignant germ cell tumor of the ovary. Department of womens diseases, karolinska sjukhuset, stockholm, sweden. Surgery followed by irradiation has resulted in excellent cure rates in early stages of this disease. A case of dysgerminoma of the right ovary is reported in a twentyseven year old white female, who had been in good health until two weeks before entry into the hospital, with the symptoms of abdominal distention, pulling sensation in both flanks, backache and pain radiating to both shoulders. However, this entity in not recognized in the who classification of tumours of genital system of domestic animals. Pdf ovarian dysgerminoma od is one of the most common malignant tumours of the ovarian germ cells. Download fulltext pdf ovarian dysgerminoma in an adolescent. In 1931, meyer first applied the term dysgerminoma to the ovarian counterpart of the testicular seminoma. Eighty percent of these maligant tumor cases occur during 2nd and 3rd age decades and their mean and median occur in late teens and early twenties. The first page of the pdf of this article appears above. Dysgerminoma of the ovary dysgerminoma of the ovary jose, baby. Dysgerminomas occur most often in the ovaries, but they may also occur in other areas of the body, including the central nervous system. When dissected, they look white and homogeneous and sometimes have necrotic areas fig.
A case of dysgerminoma of the ovary with early carcinomatous. Herein, we describe a case of ovarian gonadoblastoma. Background female malignant ovarian germ cell tumours mogcts are rare, but early diagnosis and multiagent chemotherapy are 1associated with high cure rates of 85. Dysgerminoma is composed entirely of germ cells that show morphologic and histochemical similarity to primordial germ cells. Expression of cd117 ckit receptor in dysgerminoma of. Ovarian dysgerminoma medigoo health medical tests and. In all, 30 cases of dysgerminoma of the ovary accessioned from 1982 to 2002 were retrieved from the surgical pathology files of three institutions. Chromosome 12p abnormalities in dysgerminoma of the ovary. Dysgerminoma is the most common malignant ovarian germ cell tumor and shares histological and immunophenotypical features with its testicular counterpart, seminoma. Thank you for your interest in spreading the word about the bmj. They are the most common malignant germ cell tumors of the ovary and are thought to account for 1% of all ovarian neoplasms 5.
View enhanced pdf access article on wiley online library. Dysgerminoma of the ovary nystrom 1956 acta obstetricia. The rarity of ovarian tumors in children and adolescents does not. These are uncommon neoplasms that correspond to less than 1% of all malignant ovarian tumors. Depending on the figo stage at presentation the prognosis of dysgerminomas after surgical treatment, adjuvant chemotherapy, and radiotherapy is promising. Her left ovary was the size of a football the normal size is more like an almond. In a study by weinberg et al, 40 women with malignant ovarian gcts were followed for reproductive. A dysgerminoma refers to a class of tumor with germ cell origin. Dysgerminoma usually occurs in adolescence and early adult life. Jan 23, 2020 additionally, note that the contralateral ovary may be involved in 510% of patients who appear to have stage ia disease.
The patients medical history led us to conclude that uterine myoma was a misdiagnosis and that. Germ cell tumors arise from primordial germ cells of the ovary and the testis. The biopsy from other ovary, peritoneal surface, omentum and paraarotic lymph nodes were negative for malignancy. Full text full text is available as a scanned copy of the original print version. Dysgerminoma disease staged below ia ie, confined within the capsule of only 1 ovary is best treated with simple unilateral salpingooophorectomy. Ovarian dysgerminoma is a rare malignant ovarian germ cell tumor with its peak incidence in young women. Dysgerminoma presentation solid, lobulated, and can be large 15% associated with mct associated with gonadal dysgenesis and gonadoblastoma high growth fraction, lymphatic spread tumor markers ldh, placental alkaline phosphatase survival overall 86% stage i. Dysgerminoma of the ovary, acta obstetricia et gynecologica. Jul 22, 2005 in all, 30 cases of dysgerminoma of the ovary accessioned from 1982 to 2002 were retrieved from the surgical pathology files of three institutions.
Dysgerminoma of the ovary, journal of surgical oncology. Unlimited viewing of the articlechapter pdf and any associated supplements and. Hcg more commonly points to the possibility of an ectopic pregnancy rather than an ovarian malignancy. Hugh jeter, who made a diagnosis of malignant dysgerminoma. Olson, in lanzkowskys manual of pediatric hematology and oncology sixth edition, 2016. Dysgerminoma definition of dysgerminoma by medical dictionary. Management of female malignant ovarian germ cell tumours. Large, clear, neoplastic, primitivetype germ cells are consistently associated with a variable cytotoxic tcell lymphocytic response20 that helps to identify the tumor, even in cases with complex histology. A case of dysgerminoma of the ovary with early carcinomatous features. Dec 23, 2019 a dysgerminoma is a tumor of the ovary that is composed of primitive, undifferentiated germ cells. It is usually seen in patients 30 years of age, but can be seen both in premenopausal and postmenopausal women, albeit rarely. Amongst these tumours there are some groups, characterized by similar clinical, histological, and histogenic features, which stand out.
Gonadoblastoma gb is a rare mixed germ cellsex cordstromal tumour, first described in humans, commonly found in dysgenetic gonads of intersex patients that have a y chromosome. It is important that therapy of ovarian dysgerminoma be optimized because of the young age of women affected and the threat that therapy may pose to fertility. One percent of all ovarian cancers are dysgerminoma cases. Dysgerminoma of the ovary is a rare type of primitive germ cell tumor accounting for 12% of all ovarian neoplasms.
Dysgerminoma online pathology video lecturio online. Cns dysgerminoma ovarian dysgerminoma see also germ cell tumors. The germ cells of gonadoblastoma and dysgerminoma components were immunoreactive for ckit. Epidemiology they are rare ovarian tumors that occ.
An ovarian dysgerminoma is a rare, malignant tumor occurring in young women, accounting for 1% to 2% of all primary ovarian neoplasms. Approximately 65% of patients present with stage ia disease. Dysgerminomas of the ovary are rare germ cell tumors. Article information, pdf download for ovarian dysgerminoma presenting as a pregnancy. The other complications of ovarian dysgerminoma may include. Read more about symptoms, diagnosis, treatment, complications, causes and prognosis. Department of pathology, showa university northern yokohama hospital,histochemical laboratory. Dysgerminoma symptoms, diagnosis, treatments and causes. A rare form of cancer of the germ cells in the ovary. Canine ovarian gonadoblastoma with dysgerminoma overgrowth. All patients presented first with abdominopelvic mass. Dysgerminoma is the most common malignant germ cell tumor of the ovary. Get a printable copy pdf file of the complete article 235k, or click on a page image below to browse page by page. Definition of dysgerminoma nci dictionary of cancer.
Dysgerminomas are generally solid and large with a white surface and are plain or irregular. Download fulltext pdf download fulltext pdf dysgerminoma and pregnancy article pdf available in srpski arhiv za celokupno lekarstvo 14500. Pdf ovarian dysgerminomas are rare entity and account for only about 2%of all malignant ovarian neoplasm. These tumours were first described by c h e n o t 1911 and the name dysgerminoma was introduced by r o b. Although there are approximately 200 cases reported in the literature up to 1939 1, the dysgerminoma is a relatively uncommon ovarian neoplasm, its frequency being variously reported as 3 to 10 per cent of primary malignant tumors of the ovary 1, 5, 6, 7. Late recurrence in ovarian dysgerminoma presenting as a. Advanced ovarian dysgerminoma infiltrating both ovaries. Abdominal pain, abdominal distention, and the presence of a palpable mass are common symptoms at presentation.
Depending on the figo stage at presentation the prognosis of dysgerminomas after surgical treatment, adjuvant chemotherapy, and. Microscopic sections of the ovarian tissue were examined by dr. Sep 23, 2019 microscopically, the ovary was almost replaced by an irregular neoplasm composed of three distinct, intermixed elements. Dysgerminoma occurs in both ovaries in 10% of patients and, in a further 10%, there is microscopic tumor in the other ovary. Dysgerminoma of the ovary in association with xy gonadal. Ovarian dysgermination is most common maligant germ cell tumor gct of ovary. Management of female malignant ovarian germ cell tumours 1. Dysgerminoma of the ovary with widespread metastases. Most common malignant germ cell tumor of ovary 50% most common in children and young women. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.
Pdf ovarian dysgerminoma disgerminom jajnika researchgate. A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. Dysgerminoma medigoo health tests and free medical. Ovarian dysgerminomas primarily affect adolescents and young adults, with about 60% diagnosed in patients younger than 20 years median age at diagnosis. Our understanding of dysgerminoma has improved, so that treatment schemes with better therapeutic ratio may now be used. Ovarian gonadoblastoma with dysgerminoma in a young girl with. Malignant ovarian germ cell tumors mogcts are rare, accounting for. A dysgerminoma is a tumor of the ovary that is composed of primitive, undifferentiated germ cells.
This is encapsulated with smooth or bossellated external surface. It is the most common type of malignant germ cell ovarian cancer, but accounts for less than 1 percent of ovarian tumors overall dysgerminoma usually develops in adolescents, particularly prepubescents, and rarely develops in patients over 50. In studies of young women who received platinumbased chemotherapy for ovarian germ cell tumors gcts, 62 87% of 71 resumed regular menstrual function and 24 of these women delivered 37 children after chemotherapy. Management of bilateral malignant ovarian germ cell tumors. Dysgerminoma definition of dysgerminoma by medical. Hi, i just wanted to say that my stepdaughter was diagnosed at 16 with ovarian dysgerminoma. The most common clinical presentation of an ovarian dysgerminoma is a young patient with subacute, lower quadrant pain and a palpable pelvic mass by clinical examination. Dysgerminoma of the ovary, journal of surgical oncology 10. Mar 16, 2006 dysgerminoma is the most common malignant ovarian germ cell tumor and shares histological and immunophenotypical features with its testicular counterpart, seminoma. Tumor often separated by fibrous septae containing cytotoxic lymphocytes that can spill out into tumor. This malignancy can be associated with pure gonadal dysgenesis or swyer syndrome, mixed gonadal dysgenesis and partial gonadal dysgenesis. Dysgerminoma accounts for less than 1% of ovarian tumors overall. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. She had no other treatment but her ca125 is and was being monitored.
View the article pdf and any associated supplements and figures for a period of 48 hours. Emil novak, who were requested to examine these tissues, expressed a similar opinion. Immunohistochemistry was suggested for confirmation and to rule out mixed tumor variant. Ovarian germ cell tumor is a disease in which malignant cells form in the germ egg cells of the ovary. Ovarian dysgerminoma is a common malignant tumor that comprises of ovarian germ cells. Historically, a wedge biopsy of the contralateral ovary was recommended to rule out microscopic spread in that ovary. Ovarian dysgerminoma description, causes and risk factors.
Dec 14, 2018 the main complication of ovarian dysgerminoma is infertility due to invasion of ovary by tumor or due to side effect of chemotherapy. Dysgerminoma is a germ cell tumor and a type of malignant ovarian cancer. Dysgerminoma is a malignant germ cell tumor of the ovary believed to arise from primordial germ cells, similar to the testicular seminoma counterpart. Dysgerminoma ovary this is the ovarian counterpart of seminoma in males. Dysgerminoma of the ovary hedberg 1955 acta obstetricia. A biopsy should be performed on the contralateral ovary at the time of surgery if the ovary is enlarged or appears abnormal. Germ cell tumors of the ovary archives of pathology. Ovarian dysgerminomas are a type of germ cell tumor of the ovary.
There may be a rapid growth of the tumor which may invade into surrounding tissue causing tissue damage. The main complication of ovarian dysgerminoma is infertility due to invasion of ovary by tumor or due to side effect of chemotherapy. Germ cells are cells that form sperm in males or eggs in females. It is diagnosed by physical examination and imaging methods and is treated by salpingooophorectomy, radiation, and chemotherapy. Their patient received 10 courses of chemotherapy and was free of relapse after 2 years of surgery. Bilateral ovarian involvement occurs in 1015% of dysgerminoma patients 8. A case of dysgerminoma of the right ovary is reported in a twentyseven year old white female, who had been in good health until two weeks before entry into the hospital, with the symptoms of abdominal distention, pulling sensation in both flanks, backache and pain radiating to. Stage ia dysgerminoma is a fertilitypreserving surgical approach.
The controversy on the use of irradiation in stage. Pure dysgerminoma of the ovary is rare accounting for 0. Dysgerminoma is the most frequent malignant germ cell tumor of the ovary. Dysgerminoma in three patients with swyer syndrome world. Ovarian germ cell tumor dysgerminoma cleveland clinic. Advanced ovarian dysgerminoma infiltrating both ovaries and. The classification of primary ovarian tumours has always been an intricate field of gynaxological pathology. Cut surface will be fleshy and solid, which is greywhite to yellowish. More detailed information about the symptoms, causes, and treatments of dysgerminoma is available below symptoms of dysgerminoma. Dysgerminoma developed in 3 phenotypic female patients with 46 xy pure gonadal dysgenesis. H erewith is presented a case of a dysgerminoma of the right ovary which followed a rapidly fatal course.
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